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肠道微生态与健康研究团队    研究员

研究领域：

  主要研究方向肠道菌群与健康和疾病，内容涉及系√统微量元素代谢、肌肉干细胞和脂肪的生理调控机制以及肠道菌群与宿主营养代谢相互调节机理在代谢性疾病中的作用机制和转化╱应用。

     2019年 广东省自然科学杰出青年

  南方医科大学特聘教授，博士生导师；新乡医学院特聘教授，硕士生导师。

通讯（共同◥通讯作者）作者文章 ：

1. G. Pan, B. Liu, S. Li, M. Han, L. Gao, G. Xu, Q. Du, L. Xie. Kuijieling, A Chinese medicine alleviates DSS-induced colitis in C57BL/6 J mouse by improving the diversity and function of gut microbiota . FEMS Microbiol Lett. 2020.

2. Z. Liu # , C. Cai # , J. Du # , B. Liu, L. Cui, X. Fan, Q. Wu, J. Fang * , L. Xie * .  TCMIO: A Comprehensive Database of Traditional Chinese Medicine on Immuno-Oncology. Front Pharmacol. 2020;11:439

3. J. Li # , X. Pan # , Gu. Pan, Z. Song, Y. He, S. Zhang, X. Ye, X. Yang, E. Xie, X. Wang, X. Mai, X.Yin, B. Tang, X. Shu, P. Chen, X. Dai, Y. Tian, L. Yao, M. Han, G. Xu, H. Zhang, J. Sun, H. Chen, F. Wang*, J. Min* and L. Xie*.Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes. Advanced Science, 2020.

4. B. Liu, X. Pan, Z. Liu, M. Han, G. Xu, X. Dai, W. Wang, H. Zhang, L. Xie. Fecal microbiota as a non-invasive biomarker to predict the tissue iron accumulation in intestine epithelial cells and liver. FASEB J. 2020;34(2):3006–3020.

5. Y. Wu, Y.g Gong, Y. Luan, Y. Li, J. Liu, Z. Yue, B. Yuan, Ji. Sun, C. Xie, L. Li, J. Zhen, X. Jin,Y. Zheng, X. Wang, L. Xie, W. Wang.  BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease. FASEB J. 2020;34(1):1412–1429.

6. H. Li, B. Liu, J. Song, Z. An, X. Zeng, J. Li, J. Jiang, L. Xie, W. Wu. Characteristics of Gut Microbiota in Patients with Hypertension and/or Hyperlipidemia: A Cross-Sectional Study on Rural Residents in Xinxiang County, Henan Province. Microorganisms, 2019 Sep 26;7(10). pii: E399

7. Z. Liu, D. Ji, J. Fang, Y. Yin, G. Xu, L. Xie. DeepScreening: a deep learning-based screening web server for accelerating drug discovery. Database ,  2019:baz104. doi:10.1093/database/baz104

8. S. Chen, H. Ding, X. Yao, L. Xie. Isolation and culture of single myofiber and immunostaining of satellite cells from adult C57BL/6J mice. Bio-protocol 9(14): e3313

9. B. Liu, W. Lin, S. Chen, T. Xiang, Y. Yang, Y. Yin, G. Xu, Z. Liu, L. Liu, J. Pan, L. Xie. Gut microbiota as an objective measurement for auxiliary of insomnia disorder. Front. Microbiol. 10:1770. doi: 10.3389/fmicb.2019.01770

10. B. Liu, X. Pan, L. Yao, S. Chen, Z. Liu, M. Han, Y. Yin, G. Xu, D. Wan, X. Dai, J. Sun, J. Pan, H. Zhang, W. Wang, L., L. Xie. Fecal microbiota as a non-invasive biomarker to predict the tissue iron accumulation in intestine epithelial cells and liver. bioRxiv.2019. Jan 2019:612168.

11. S. Herrlinger, Q. Shao, M, Yang, Q. Chang, Y, Liu, X. Pan, H. Yin, L. Xie, J. Chen. Lin28-mediated promotion of protein synthesis is critical for neural progenitor cell maintenance and brain development in mice. Development, 2019,146 (10), dev173765.

12. X. Pan, B. Liu, S. Chen, H. Ding, X. Yao, Y. Cheng, D. Xu, Y. Yin, X. Dai, J. Sun, G. Xu, J. Pan, L. Xiao, L. Xie. Nr4a1 as a myogenic factor is upregulated in satellite cells/myoblast under proliferation and differentiation state. BBRC, 2019 Jun 4;513(3):573-581

13. X. Yao, T. Yu, F. Xi, Y. XU, L. Ma, X. Pan, S. Chen, M. Han, Y. Yin, X. Dai, G. Xu, H. Zhang, G. Yang, L. Xie. BAMBI shuttling between cyto and membrane is required for skeletal muscle development and regeneration. BBRC, 2019 Jan 29; 509(1): 125-132

14. W. Li, X. Pan, W. Chen, Y. Yin, J. Chen, G. Xu, L. Xie. Serum biochemistry, histology and transcriptomic profile analysis reflect liver inflammation and damage following dietary histamine supplementation in yellow catfish (Pelteobagrus fulvidraco). Fish Shellfish Immuno. 2018 Mar 20;77:83-90

15. G. Chen, B. Huang, S. Fu, B. Li, X. Ran, D. He, L. Jiang, Y. Li, B. Liu, L. Xie, J. Liu, W. Wang. G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis. Front Immunol. 2018 Sep 13;9:2079

16. X. Tong, Q. Zhang, L. Wang, Y. Ji, L. Zhang, L. Xie, W. Chen, H. Zhang. RNF186 impairs insulin sensitivity by inducing ER stress in mouse primary hepatocytes. Cell Signal. 2018 Dec;52:155-162

17. L. Wang, X. Tong, F. Gu, L. Zhang, W. Chen, X. Cheng, L. Xie, Y., Chang, and H. Zhang, The KLF14 Transcription Factor Regulates Hepatic Gluconeogenesis in Mice. Journal of Biological Chemistry 292 (52):21631–42.

第一（共同第一）作者文章 ：

1. L.Xie, A. Yin, A.S. Nichenko, A.M. Beedle, J.A. Call, H.Yin, Transient HIF2a Inhibition Accelerates Muscle Regeneration by Promoting Satellite Cell Proliferation. J Clin Invest. 2018 Jun 1;128(6):2339-2355.

2. L.Xie, X. Xue, M. Taylor, S.K. Ramakrishnan, K. Nagaoka, C. Hao, F.J. Gonzalez, Y.M. Shah, Hypoxia-Inducible Factor/MAZ-Dependent Induction of Caveolin-1 Regulates Colon Permeability through Suppression of Occludin, Leading to Hypoxia-Induced Inflammation, Mol. Cell. Biol. 34 (2014) 3013–3023.

3. L.Xie, J.F. Collins, Copper stabilizes the Menkes copper-transporting ATPase (Atp7a) protein expressed in rat intestinal epithelial cells, AJP Cell Physiol. 304 (2013) C257–C262.

4. L.Xie, J.F. Collins, Transcription Factors Sp1 and HIF2a Mediate Induction of the Copper- transporting ATPase (Atp7a) Gene in Intestinal Epithelial Cells during Hypoxia, J. Biol. Chem. 288 (2013) 23943–23952.

5. L.Xie, J.F. Collins, Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2a) in intestinal epithelial cells, AJP Cell Physiol. 300 (2011) C1298–C1305.

6. W. Qin, X. Li, L.Xie, S. Li, J. Liu, L. Jia, X. Dong, X. Ren, J. Xiao, C. Yang, Y. Zhou, Z. Chen, A long non-coding RNA, APOA4 -AS, regulates APOA4 expression depending on HuR in mice, Nucleic Acids Res. 44 (2016) 6423–6433.

7. C. Cao, T. Zhang, D. Zhang, L.Xie, X. Zou, L. Lei, D. Wu, L. Liu, The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma., Oncogene. (2016).

8. X. Zhu, Q. Kong, L.Xie, Z. Chen, H. Li, Z. Zhu, Y. Huang, F. Lan, H. Luo, J. Zhan, H. Ding, J. Lei, Q. Xiao, W. Fu, W. Fan, J. Zhang, H. Luo. The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma. Oncotarget. 2017 Dec 26;9(17):13222-13230.

非通讯或非第一作者文章 ：

1. Y. Wang, M. Gao, F. Zhu, X. Li, Y. Yang, Q. Yan, L. Jia, L.Xie, Z. Chen. METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice. Nature Communication, 2020, In press.

2. T. Zeng, Z. Liu, H. Liu, W. He, X. Tang, L.Xie, R. Wu. Exploring chemical and biological space of terpenoids. J Chem Inf Model, J Chem Inf Model. 2019;59(9):3667–3678.

3. W. Li, Y. Li, Y. Hu, X. Mo, G. Xu, L.Xie, A. Li. GroEL, a novel vaccine candidate of piscine Streptococcus agalactiae identified by immunoproteome. Fish Shellfish Immuno. 2019. 84, 377-383.

4. X. Li, L. Jia, X. Chen, Y. Dong, X. Ren, Y. Dong, Y. Chen, L.Xie, M. Liu, C. Shiota, G.K. Gittes, L. Rui, Z. Chen. Islet-cell inflammation induced by NF-kB Indcuing kinase (NIK) leads to hypoglycemia, pancreatitis,growth retardation and postnatal death in mice. Theranostics. 2018;8(21):5960-5971.

5. Y. Long, S. Li, J. Qin, L.Xie, L. Gan, F. Jie, Y. Wu, Y. Li, Q. Du.Kuijieling regulates the differentiation of Treg and Th17 cells to ameliorate experimental colitis in rats. Biomed Pharmacother. 2018 Sep;105:781-788

6. Y.M. Shah, L.Xie, Hypoxia-Inducible Factors Link Iron Homeostasis and Erythropoiesis, Gastroenterology. 146 (2014) 630–642.

7. C. Cao, J. Sun, D. Zhang, X. Guo, L.Xie, X. Li, D. Wu, L. Liu, The Long Intergenic Noncoding RNA UFC1, a Target of MicroRNA 34a, Interacts With the mRNA Stabilizing Protein HuR to Increase Levels of β-Catenin in HCC Cells, Gastroenterology. 148 (2015) 415–426.e18.

8. E.R. Anderson, M. Taylor, X. Xue, S.K. Ramakrishnan, A. Martin, L.Xie, B.X. Bredell, S. Gardenghi, S. Rivella, Y.M. Shah, Intestinal HIF2 promotes tissue-iron accumulation in disorders of iron overload with anemia, Proc. Natl. Acad. Sci. 110 (2013) E4922–E4930.

9. N. Das, L.Xie, S.K. Ramakrishnan, A. Campbell, S. Rivella, Y.M. Shah, Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease, J. Biol. Chem. 290 (2015) 23523–23527.

10. L. Gan, L.Xie, F. Zuo, Z. Xiang, N. He, Transcriptomic analysis of Rongchang pig brains and livers, Gene. 560 (2015) 96–106.

11. H. Zhang, Q. Chen, T. Jiao, A. Cui, X. Sun, W. Fang, L.Xie, Y. Liu, F. Fang, Y. Chang, Involvement of KLF11 in Hepatic Glucose Metabolism in Mice via Suppressing of PEPCK-C Expression, PLoS One. 9 (2014) e89552.

12. X. Xue, S.K. Ramakrishnan, K. Weisz, D. Triner, L.Xie, D. Attili, A. Pant, B. Gy？rffy, M. Zhan, C. Carter-Su, K.M. Hardiman, T.D. Wang, M.K. Dame, J. Varani, D. Brenner, E.R. Fearon, Y.M. Shah, Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis, Cell Metab. 24 (2016) 447–461.

1. 专利申请号：201910234195.9，受理日期：2019年 03月 26日，申请国家：中国

2. 专利申请号：201910309446.5，受理日期：2019年 04月 17日，申请国家：中国

3. 专利申请号：201910315091.0，受理日期：2019年 04月 19日，申请国家：中国

主持项目（省部级以◣上）：

1. 广东省基础与应用基础杰出青年基金（￥100 万）  2020 年-2023 年

2. 国家自然基金青年项目（￥22万）  2020年 1月-2022年 12月

3. 国家自然基金ζ面上项目（￥55万）  2021年 1月-2024年 12月