广东省微生物研究所

食用菌研究发展中心副研究员

研究领域：

基于微生◣物组学的“肠脑轴”代谢调控网络机制研究；

环状RNA在阿尔茨海默ζ症中的功能机制研究。

获奖、荣誉及国内外学术团体任职情况∞：

广东省食用菌行业协会』副秘书长

中国肠微生态—疾病整合↙联盟专家委」员会成员

代表论著：

1. Chen Diling^#, Qi Longkai^#, Guo Yinrui, Liu Yadi, Tang Xiaocui, Zhu Xiangxiang, Zeng Miao, Li Ran, Shuai Ou, Wang Dongdong, Xie Yizhen, Yuan Xujiang*, Burton B. Yang, Wu Qingping*. CircNF1-419 improves the gut microbiome structure and function in AD-like mice. Aging. 2020; 12(1):260-287.

2. Chen Diling^#, Guo Yinrui^#, Qi Longkai^#, Tang Xiaocui, Liu Yadi, Feng Jiaxin, Zhu Xiangxiang, Zeng Miao Zeng, Shuai Ou, Wang Dongdong, Xie Yizhen, Burton B Yang*, Wu Qingping*. Metabolic regulation of Ganoderma lucidum extracts in high sugar and fat diet-induced obese mice by regulating the gut-brain axis. Journal of Functional Foods. 2020; 65:103639.

3. Lai Guoxiao^#, Guo Yinrui^#, Chen Diling*, Tang Xiaocui, Shuai Ou, Yong Tianqiao, Wang Dongdong, Xiao Chun, Zhou Gailian, Xie Yizhen*, Burton B. Yang, Wu Qingping. Alcohol extracts from Ganoderma lucidum delay the progress of Alzheimer's disease by regulating DNA methylation in rodents. Frontiers in Pharmacology. 2019; 10: 272.

4. Chen Diling^#, Guo Yinrui^#, Qi Longkai, Tang Xiaocui, Liu Yadi, Yang Xin, Hu Guoyan, Shuai Ou, Yong Tianqiao, Wang Dongdong, Xie Yizhen, Burton B. Yang*, Wu Qingping*. Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice. Aging. 2019; 11(24): 12002-12031.

5. Yang Xin^#, Chen Diling^#*, Yang Jian, Liu Ting, Hu Guoyan, Liang Hualun, Tang Xiaocui, Lai Guoxiao, Shuai Ou, Zheng Chaoqun, Zhao Jun, Xie Yizhen. Effects of oligosaccharides from Morinda officinalis on gut microbiota and metabolome of APP/PS1 transgenic mice. Frontiers in Neurology. 2018; 9: 412.

6. Chen Diling^*, Yang Xin, Yang Jian, Lai Guoxiao, Yong Tianqiao, Tang Xiaocui, Shuai Ou, Zhou Gailian, Xie Yizhen^*, Wu Qingping. Prebiotic effect of fructooligosaccharides from Morinda officinalis on Alzheimer’s disease in rodent models by targeting the microbiota-gut-brain axis. Frontiers in Aging Neuroscience. 2017; 9: 403.

7. Chen DL, Zheng CQ, Yang J, Li J, Su JY, Xie YZ, Lai GX. Immunomodulatory activities of a fungal protein extracted from Hericium erinaceus through regulating the gut microbiota. Frontiers in Immunology, 2017, 8:666

8. Chen DL, Yong TQ, Yang J, Zheng CQ, Shuai O, Xie YZ. Docking studies and biological evaluation of a potential β-Secretase inhibitor of 3-Hydroxyhericenone F from Hericium erinaceus. Frontiers in Pharmacology, 2017, 8:219.

授权专利：

1. 陈地灵，郭殷锐，祁龙凯，吴清平，谢意珍, 唐晓翠，王东东. CircRNA PVT1及其肽段PVT1-104aa在抗衰老方面的应用. 中国专利号：202010311937.6

2. 陈地灵，郭殷锐，祁龙凯，吴清平，谢意珍, 唐晓翠，王东东. CircZCCHC11及其翻译的肽★段ZCCHC11-274aa在肿瘤生长预①测、转移预测、预后▓评估和治疗中的应用. 202010312634.6

3. 陈地灵，郭殷锐，祁龙凯，唐晓翠，吴清平，谢意珍. CircRNA PVT1核酸片段及肽段PVT1-104aa在肿∴瘤生长预测、转移预测、预后评估和治☉疗中的应用. 中国√专利申请号201911358263.9，国际专利申请※号PCT/CN2020/071984.

4. 陈地灵，杨俭，帅欧，谢意珍，吴清平. 黑虎掌提取物在制备抗前列腺癌药物、保健品或食品中的应用，发明专利申请号201710352457.2

主持项目（省ω　部级以上）：

1. 国家自然科学基金青年基金“CircNF1-419对星形胶质细胞功能的影响及其在AD发病过程中的调控机【制研究”，编号81701086，主持，在研；

2. 广东省自然科学基金 “基于线粒体保护机制的巴戟天低聚糖延缓神经干细胞衰老机制研究”（S2013040016159），主持，结题。

3. 广东省科技计划国际科技合作项目“基于circRNA细胞周期调控功能的食药用菌中抗神经细胞衰老活性成分筛选及机制研究”，编号2016A050502032，主持，已结题；

4. 广东省科技计划项●目“特色南药巴戟天低聚糖抗AD新药成药性＠研究”，编号2015A020211021，主持，已结题；

5. 广州市科技计划产学研重点专项“食药用真菌猴头菌辅助增强记忆特色健康产品研发”，编号201604020009，主持，已结题；

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